What Is Nabota Botulinum Toxin?
Nabota is a highly purified botulinum toxin type A manufactured by Daewoong Pharmaceutical in South Korea. It is manufactured using a patented process designed to minimize impurities. The commonly used Nabota vial strengths include 100 U and 200 U. It is used in aesthetic applications such as the temporary improvement of glabellar lines and in certain medical applications, including focal axillary hyperhidrosis.
Physical Appearance and Reconstitution
Nabota is supplied as a white to light yellow lyophilized powder in a transparent vial. Due to the vacuum present during manufacturing, the vial may appear empty at first glance—this is normal.
For reconstitution, the powder should be dissolved with 0.9% Sodium Chloride Injection (nonpreserved sterile saline). Upon proper reconstitution, the solution becomes clear and transparent, free of visible particles.
General Dilution Guidance:
-
For a 100 U vial: add 2.5 mL of saline
-
For a 200 U vial: add 5.0 mL of saline
Note: These are recommended starting volumes. Practitioners may adjust the dilution volume based on clinical indication, treatment area, and individual patient assessment.
Areas of Application
Nabota is commonly used to address the following aesthetic and therapeutic concerns:
-
Glabellar Lines (frown lines between the eyebrows)
-
Forehead Lines
-
Crow’s Feet
-
Brow Lift
-
Bunny Lines (nasal wrinkles)
-
Jawline Contouring (masseter reduction)
-
Neck Bands (platysmal bands)
-
Excessive Sweating (axillary hyperhidrosis)
Reconstitution and Dilution Procedure
The following general principles apply when preparing Nabota for administration:
-
Prepare the saline: Using an appropriate sterile syringe, draw the required volume of nonpreserved 0.9% Sodium Chloride Injection.
-
Inject the diluent: Insert the needle into the Nabota vial (which contains a vacuum) and slowly inject the saline. Injecting slowly helps minimize foam formation.
-
Mix gently: Swirl or roll the vial gently until the lyophilized powder is completely dissolved. Avoid vigorous shaking, which may denature the toxin.
-
Inspect the solution: Visually inspect the reconstituted solution. A properly prepared solution should be clear, colorless, and free of visible particles. If any cloudiness, discoloration, or particulate matter is observed, the solution should not be used.
-
Record preparation time: Note the date and time of reconstitution on the vial label.
-
Storage: Reconstituted product should be stored in a refrigerator at 2–8°C (36–46°F) and administered within 24 hours of reconstitution.
Nabota Dilution Reference Chart
The following table provides a quick reference for reconstituting Nabota vials to achieve common concentration levels:
Key Clinical Considerations for Dilution
1. Understanding Units vs. Concentration
A 100 U vial contains 100 units of active toxin regardless of how much saline is added. The dilution volume affects the concentration (Units per mL), not the total available toxin. Adding more saline does not increase the amount of Nabota—it only decreases the concentration per injection volume.
2. Choosing a Dilution Volume
The appropriate dilution volume depends on the treatment indication:
| Dilution per 100 U | Concentration | Typical Applications |
|---|---|---|
| 1.0–1.5 mL | Higher concentration | Small muscles, precise targeting (masseter, glabellar) |
| 2.0–2.5 mL | Moderate concentration | Forehead lines, crow’s feet, hyperhidrosis |
| 2.5 mL+ | Lower concentration | Broad areas requiring wider diffusion |
Practitioners should select the dilution that best matches their injection technique, the target muscle size, and the desired diffusion pattern.
Where to Purchase Nabota
Nabota is available in 100 U and 200 U vial strengths from authorized suppliers. When purchasing, please ensure that you are eligible to acquire and use this professional-grade product, as it should only be administered by qualified healthcare providers in appropriate clinical settings.
Medical directly. For a more detailed guide on selecting a reliable supplier, you can also refer to our full article: Where to Buy Nabota Online: Finding the Best Place for Safe and Reliable Supply.
This information is for professional reference only. Nabota should only be reconstituted and administered by qualified healthcare practitioners. Always refer to the official product insert for complete prescribing information and safety data.
